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Welcome to NFL Week 2, where we will discover if our Week 1 findings were legitimate or not. Are the New England Patriots poised to start 2-0 with consecutive upset victories? Are the Cleveland Browns going to be forced to address some tough questions regarding their quarterback? Can Caleb Williams move to 2-0 by defeating C.J. Stroud and the Houston Texans in prime time? Time will tell. 

As we do every week, we've collected all of the best picks and gambling content from CBSSports.com and SportsLine and put them in one place, so you can get picks against the spread from our CBS Sports experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more. Ready? Let's jump in.

All NFL odds via SportsLine consensus odds.

Which picks can you make with confidence in Week 2? And which Super Bowl contender goes down hard? Visit SportsLine, as its incredible model simulates every NFL game 10,000 times and is up well over $7,000 for $100 players on top-rated NFL picks since its inception.

Los Angeles Rams at Arizona Cardinals

Time: Sunday, 4:05 p.m. ET (Fox), stream on fubo (try for free)
Open: Rams -2.5, O/U 49.5

"I was high on the Rams this preseason but injuries look to be a significant problem already and it's only Week 2. Star wide receiver Puka Nacua is on IR and Matthew Stafford has a shaky offensive line in front of him. Arizona played well enough to win in Buffalo, yet rookie wide receiver Marvin Harrison only had one catch for four yards. Expect Harrison to be involved early and often this week. Arizona rallies late for a last second field goal by Matt Prater to secure their first victory of 2024."

SportsLine expert Eric Cohen has made his exact NFL score predictions for Week 2 of the 2024 NFL season, and he likes the Cardinals to slide by the Rams. To read Cohen's prediction for every game on this week's NFL slate, head on over to SportsLine


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Pete Prisco
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Will Brinson
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Jared Dubin
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Ryan Wilson
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John Breech
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Tyler Sullivan
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Dave Richard
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Jamey Eisenberg
Rams at Cardinals (-1)

Cincinnati Bengals at Kansas City Chiefs

Time: Sunday, 4:25 p.m. ET (CBS), stream on Paramount+ (click here)
Open: Chiefs -6, O/U 47

"Joe Burrow is 3-1 against Patrick Mahomes, but he's just 1-8 in his career in Weeks 1-2. Mahomes on the other hand is 11-2 in Weeks 1-2. The Bengals looked pitiful at home against the team many considered to be the worst in the NFL in Week 1, and now we expect them to turn it around in Arrowhead with Tee Higgins still dealing with a hamstring injury? Plus, is Burrow's right wrist OK?

"Steve Spagnuolo is going to throw pressure at Burrow, and then the Bengals defense couldn't stop Rhamondre Stevenson. Isiah Pacheco could have a big game. With this number under six, I'll lay it with the reigning Super Bowl champions."

Jordan Dajani likes the Chiefs to improve to 2-0 ATS on the year. To check out his best bets for Week 2, click here


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Pete Prisco
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Will Brinson
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Jared Dubin
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Ryan Wilson
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John Breech
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Tyler Sullivan
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Dave Richard
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Jamey Eisenberg
Bengals at Chiefs (-5.5)

Pittsburgh Steelers at Denver Broncos

Time: Sunday, 4:25 p.m. ET (CBS), stream on Paramount+ (click here)
Open: Steelers -3, O/U 40.5

Before you make any Week 2 NFL picks or NFL parlays, you need to see what SportsLine senior analyst Larry Hartstein has to say. Hartstein tied for 52nd place (out of 1,598 entries) in the 2022 Westgate Las Vegas SuperContest, going 53-34-3 ATS. His weekly Vegas contest selections form the basis of his NFL best bets column, which is 81-49-2 (62.3%, +26.85 units) since its inception in 2022. 

As one of his best bets for Week 2, Hartstein is taking a home underdog.  

"In the win over Atlanta, the Steelers were plus-3 in turnover margin. Their offense averaged a measly 4.1 yards per play. Now they have to play a second straight road game against a Denver team playing its home opener. Bo Nix showed promise at Seattle, especially as a runner, and I trust Sean Payton to help the rookie make adjustments entering this matchup. More designed runs will be called. In what surely will be a low-scoring grinder, I like getting a full field goal with the home team."

For Hartstein's other best bets this week, head on over to SportsLine


player headshot
Pete Prisco
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Will Brinson
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Jared Dubin
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Ryan Wilson
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John Breech
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Tyler Sullivan
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Dave Richard
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Jamey Eisenberg
Steelers (-2.5) at Broncos

Chicago Bears at Houston Texans 

Time: Sunday, 8:20 p.m. ET (NBC), stream on fubo (try for free)
Open: Texans -5, O/U 40.5

Before you make any Bears vs. Texans bets or predictions, you need to see which side SportsLine NFL expert R.J. White is on. White went 636-534-34 (+4899) on ATS picks from 2017-23, and is on a 64-46-5 roll (+1539) on Bears spread picks.

We can tell you that White is leaning towards the Over in this matchup, but to check out his against-the-spread pick, head on over to SportsLine


player headshot
Pete Prisco
player headshot
Will Brinson
player headshot
Jared Dubin
player headshot
Ryan Wilson
player headshot
John Breech
player headshot
Tyler Sullivan
player headshot
Dave Richard
player headshot
Jamey Eisenberg
Bears at Texans (-6)

Atlanta Falcons at Philadelphia Eagles

Time: Monday, 8:15 p.m. ET (ESPN), stream on fubo (try for free)
Open: Eagles -4.5, O/U 48

"The Eagles will have extra rest here after playing last Friday when they beat Green Bay. The Falcons were lifeless on offense against the Steelers, while the Eagles moved it at will against the Packers. That will continue here. Kirk Cousins will be better than a week ago, but not quite what the Falcons need to win it. " -- CBS Sports Senior NFL Analyst Pete Prisco on why he likes the Eagles to edge out the Falcons, 27-24. To see all of his Week 2 picks, click here


player headshot
Pete Prisco
player headshot
Will Brinson
player headshot
Jared Dubin
player headshot
Ryan Wilson
player headshot
John Breech
player headshot
Tyler Sullivan
player headshot
Dave Richard
player headshot
Jamey Eisenberg
Falcons at Eagles (-6.5)